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Item type: Person , Item type: Item , Access status: Open Access , Investigation of sociodemographic, temporal, and meteorological heterogeneity in the short-term blood pressure response to air pollutants(2026-02-28) Maharjan, Dikshya; Bista, Sanjeev; Teyton, Anaïs; Bruno, Rosa M.; Montanari, Andrea; Zou, Dan; Fancello, Giovanna; Benmarhnia, Tarik; Chaix, BasileItem type: Item , Access status: Open Access , University students’ interest in intervention research participation is associated with gender, age and symptoms of depression, general and social anxiety, panic disorder and self-harm(2026-03-29) Irving, Elisabeth T.; Stikvoort, Britt; Andersson, Claes; Berman, Anne H.Abstract Objective Research in the mental health field has focused on exploration and implementation of digital interventions both in research and society. However, demographic and mental health factors that may influence engagement with research on such interventions have not been explored. This study aims to investigate the relationship between demographics, signs of mental disorders, and interest in participating in an intervention study. Using data collected in the Swedish arm of the World Health Organization’s World Mental Health International College Student (WHO-WMH-ICS) initiative (n = 9140), we conducted a multinomial logistic regression to assess relationships between these factors. Results Older age, as well as female and non-binary gender identities, were factors significantly associated with increased interest in the intervention study. Treatment flags, indicating fulfilment of criteria for possible mental disorder diagnosis, were significantly associated with clear interest (“yes” response) in intervention research for five of the 15 treatment flags: depression, general anxiety, social anxiety, panic disorder and self-harm. Possible interest (“maybe” response) was also indicated for four of these, excluding general anxiety. These findings may facilitate a better-informed approach to recruiting student participants for treatment research, enhancing unbiased recruitment practices, reducing treatment gaps, and increasing engagement in digital intervention studies for improved mental health.Item type: Item , Access status: Open Access , Predicting recalcitrant hyperinflammatory disease course in children with Kawasaki disease and MIS-C(2026-03-24) Satirer, Özlem; Eroglu, Fehime K.; Nordmeyer, Johannes; Kumpf, Matthias; Neunhoeffer, Felix; Icheva, Vanya; Reiser, Christiane; Buzoianu, Oana; Benseler, Susanne M.; Kuemmerle-Deschner, Jasmin B.Abstract Background Hyperinflammation ranges from monophasic to rapidly progressive, life-threatening courses. Early biomarkers to identify high-risk children are needed. Methods This single-center cohort included consecutive children with hyperinflammation between 01/2021 and 01/2024. Demographic, clinical, laboratory, cardiac imaging, and treatment data were analysed. Results Of 80 patients, 56 (70%) had a recalcitrant course. Fever was universal. Rash, mucosal involvement, and conjunctivitis were more common in the monophasic group, while abdominal pain, neurological signs, pleural effusion, lymphopenia, thrombocytopenia, hypoalbuminemia, and elevated ferritin characterised the recalcitrant group (p < 0.01). Myocarditis and reduced ejection fraction occurred only in the recalcitrant cohort; coronary artery changes were more frequent in monophasic cases (21% vs. 5%). All survived. All received IVIG; steroids and anakinra were used only in recalcitrant cases, who also had longer hospital stays, ICU admissions (21% vs. 0%, p < 0.01), and required inotropes/ventilation. Baseline SAA, IL-2R, and NT-proBNP were significantly higher in the recalcitrant cohort. In ROC analyses, NT-proBNP showed the highest diagnostic accuracy (AUC 0.912), followed by IL-2R (AUC 0.873) and SAA (AUC 0.793) (all p < 0.001). Conclusions NT-proBNP, IL-2R, and SAA were strongly associated with a recalcitrant hyperinflammatory course and may aid early prognostication and monitoring.Item type: Item , Access status: Open Access , Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS(2026-03-03) Krishnamurthy, Sruthi S.; Buzatto, Adriana Z.; Campkin, Caley; Müller, Hans-Peter; Wiesner, Diana; Weishaupt, Jochen; Klose, Veronika; Wiesenfarth, Maximilian; Elmas, Zeynep; Herrmann, Christine; Parlak, Özlem; Günther, Kornelia; Saad, Rami; Weiland, Ulrike; Dupuis, Luc; Ludolph, Albert; Li, Liang; Kassubek, Jan; Dorst, Johannes; Roselli, FrancescoAbstract Background Alterations in lipid metabolism are manifestations of amyotrophic lateral sclerosis (ALS) that contribute to the risk and rate of progression. Blood levels of triglycerides and cholesterol are altered in ALS patients and pre-symptomatic gene carriers, but mechanistic insights into these changes are lacking. Methods Serum samples from sporadic ALS patients (n = 118), mutated SOD1 and FUS/TARDBP (n = 20, 40, 17, respectively) with age and gender-matched controls (n = 96) were analysed for alterations in the angiopoietin-like protein (ANGPTL) system using enzyme-linked immunosorbent assays. SOD1G93A murine model was studied at pre-symptomatic (P50), early symptomatic (P90), and fully symptomatic (P110) stages, along with their wild-type (WT) littermates for ANGPTLs. Untargeted lipidomics on serum was performed using high-resolution liquid chromatography-mass spectrometry. Further, the involvement of the hypothalamus was studied using hypothalamic volumetry in patients and an antibody array spanning 308 proteins in mice. Results We show that mutation-specific patterns of systemic lipid abnormalities appear in ALS and that they correlate with reduced levels of angiopoietin-like proteins 3 and 4. ANGPTL-3/4, in turn, correlates with hypothalamic atrophy but not with corticospinal involvement, as determined by MRI volumetry and diffusion tensor imaging. Lipid phenotype and decreased ANGPTL in humans are recapitulated in two SOD1 murine ALS models, in which ANGPTL-3, -4, and -8 expression patterns are consistent with the repartitioning of lipid utilisation from muscles to the brown adipose tissue; systemic levels of ANGPTL-3 correlate with hypothalamic neuroinflammation and vascular permeability and with hypothalamic levels of agouti-related protein and neuropeptide Y. Conclusions These data provide a molecular mechanism linking peripheral lipid metabolism to the dysfunction of a specific hypothalamic circuit through the mediation of systemic ANGPTL-3 and -4. This finding constitutes a molecularly defined entry point to manipulate lipid metabolism in ALS.
