Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.

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dc.contributor.authorYang, Runze
dc.contributor.authorDunn, Jeff F.
dc.date.accessioned2018-10-25T15:35:41Z
dc.date.available2018-10-25T15:35:41Z
dc.date.issued2018-07-08
dc.description.abstractHypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a “hypoxia–inflammation cycle” in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS.en_US
dc.description.grantingagencyAlberta Innovates - Research Grant
dc.identifier.citationYang, R., & Dunn, J. F. (2018). Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458518791683
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33894
dc.identifier.doi10.1177/1352458518791683
dc.identifier.issn1352-4585
dc.identifier.urihttp://hdl.handle.net/1880/108913
dc.language.isoen
dc.publisherSAGE Publications
dc.publisher.departmentRadiology
dc.publisher.facultyCumming School of Medicine
dc.publisher.policyhttp://www.sherpa.ac.uk/romeo/issn/1352-4585/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectBiomarkersen_US
dc.subjecthypoxiaen_US
dc.subjectinflammationen_US
dc.titleMultiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle.en_US
dc.typejournal articleen_US

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